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A complete of three % of Lively substance is excreted in urine as unchanged active compound. Tapentadol is In addition metabolised to N-desmethyl tapentadol (13 %) by CYP2C9 and CYP2C19 and to hydroxy tapentadol (two %) by CYP2D6, that happen to be even further metabolised by conjugation. Consequently, Energetic compound metabolism mediated by cyto

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